Hydroxypropyl Cellulose(HPC)
High Substituted Hydroxypropyl Cellulose(HPC)
High Substituted Hydroxypropyl Cellulose(HPC) is a non-ionic water-soluble cellulose ether with a remarkable combination of properties. It combines aqueous and organic solvent solubility, thermoplasticity and surface activity with the thickening and stabilizing properties of other water-soluble cellulose polymers.It could be widely used in pharma, food and cosmetic
High Substituted Hydroxypropyl Cellulose(HPC) Features and Benefits
- Excellent thermoplastic and mechanical properties for tablet binding
- Soluble in aqueous and organic solvents
- Saves cost through improving yields and reducing the amount of other additives
- Fine particle size for enhanced performance when dry processing
- Products smaller tablets and improves consumer usability
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HighSubstituted Hydroxypropyl Cellulose(HPC) Applications
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High Substituted Hydroxypropyl Cellulose(HPC) specification
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HPC grade |
Molecular weight |
Viscosity(mPa.s) |
Solution concentration (%) |
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HPC-H |
1150,000 |
1500-3000 |
1% |
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HPC-M |
850,000 |
4000-6500 |
2% |
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HPC-G |
370,000 |
150-400 |
2% |
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HPC-J |
140,000 |
150-400 |
5% |
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HPC-L |
95,000 |
75-150 |
5% |
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HPC-E |
80,000 |
150-300 |
10% |
Low Substituted Hydroxypropyl Cellulose(HPC)
Low Substituted Hydroxypropyl Cellulose(HPC) is a non-ionic multi-functional excipient based on a cellulose backbone combined with a low amount of hydroxypropopyl groups.Thus, L-HPC is not soluble in water but showing swelling properties in this media. Typical applications of L-HPC are anti-capping for tableting process, binder and disintegrant ,stability enhancer of solid dosage forms
Low Substituted Hydroxypropyl Cellulose(HPC) structure
Low Substituted Hydroxypropyl Cellulose(HPC) Grades
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Grades |
Hydroxypropyl content，% |
Particle Size |
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LH-11 |
10.0-12.9 |
55μm |
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LH-21 |
10.0-12.9 |
45μm |
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LH-22 |
7.0-9.9 |
45μm |
Low Substituted Hydroxypropyl Cellulose(HPC) Features and Benefits
- As a excellent dispersant and binder in tablet compression
- Greatly improve the moisture absorption rate and enhance the swelling property, thereby accelerating the disintegration of tablets, accelerating drug dissolution and improving bioavailability
- It can improve the hardness and glossiness of tablets and enhance the molding efficiency and effect of drugs that are difficult to mold.
Low Substituted Hydroxypropyl Cellulose(HPC) Application in pharma grade:
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HPC&L-HPC
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Product Type |
H-HPC |
L-HPC |
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Hydroxypropyl Groups,% |
USP/NF:53.4%-77.%
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USP/NF:10.0-12.9% |
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PH |
USP/NF:5.0-8.0 |
USP/NF:5.0-7.5 |
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Solubility |
Soluble in cold water, methanol, ethanol, propylene glycol |
Insoluble in water, ethanol, acetone, ether |
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Loss on drying,% |
≤5.0 |
≤5.0% |
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Application |
Binder, film former, gel skeleton |
Binder, disintegrant |
Package
Storage
During Storage, please have to protect the product contact with moisture,prolonged storage at temperature above 30℃,carefully store it in a warehouse that provides cool and dry conditions.
